SR-3576

• CAT Number: I011085
• CAS Number: 1164153-22-3
• Molecular Formula: C27H27N5O5
• Molecular Weight: 501.53
• Purity: ≥95%
• Synonyms: 3-[4-[(3-methylphenyl)carbamoylamino]pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide
• InChI: InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34)
• InChIKey: MTFAYLZZDJGFGV-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC=C1)NC(=O)NC2=CN(N=C2)C3=CC=CC(=C3)C(=O)NC4=CC(=C(C(=C4)OC)OC)OC

SR-3576（Cat No.:I011085）is a selective small-molecule inhibitor of cyclin-dependent kinase 9 (CDK9), a key regulator of transcriptional elongation through phosphorylation of RNA polymerase II. By inhibiting CDK9 activity, SR-3576 disrupts transcription of genes involved in cell survival and proliferation, particularly in cancer cells dependent on oncogenic transcription programs. It has demonstrated antiproliferative effects in preclinical models of hematologic malignancies and solid tumors. SR-3576 is widely used to explore transcriptional regulation, CDK9 signaling, and therapeutic strategies targeting transcriptional addiction in cancer. It serves as a valuable tool in cancer biology and drug development.