For research use only. Not for therapeutic Use.
SR-31747(CAT: I009359) is a potent sigma ligand with immunosuppressive and anti-inflammatory activity. It inhibits sterol isomerase, thereby blocking cell proliferation. In vitro, SR-31747 suppresses lymphocyte proliferation at 10 nM and prevents T-cell expansion even when added 24 hours post-activation. It also induces dose-dependent growth arrest in yeast. In vivo, SR-31747 inhibits lipopolysaccharide-induced IL-1, IL-6, and TNF-α production (ED₅₀ = 2 mg/kg), likely via an indirect corticosteroid-mediated pathway. This compound elevates corticosterone levels, and its effects are abolished by adrenalectomy or Mifepristone. SR-31747 improves survival in endotoxin shock, highlighting its therapeutic potential in immune modulation.
| CAS Number | 132173-07-0 |
| Synonyms | N-[(Z)-3-(3-chloro-4-cyclohexylphenyl)prop-2-enyl]-N-ethylcyclohexanamine;hydrochloride |
| Molecular Formula | C23H35Cl2N |
| Purity | ≥95% |
| IUPAC Name | N-[(Z)-3-(3-chloro-4-cyclohexylphenyl)prop-2-enyl]-N-ethylcyclohexanamine;hydrochloride |
| InChI | InChI=1S/C23H34ClN.ClH/c1-2-25(21-13-7-4-8-14-21)17-9-10-19-15-16-22(23(24)18-19)20-11-5-3-6-12-20;/h9-10,15-16,18,20-21H,2-8,11-14,17H2,1H3;1H/b10-9-; |
| InChIKey | HKHPCMBPASXYGP-KVVVOXFISA-N |
| SMILES | CCN(CC=CC1=CC(=C(C=C1)C2CCCCC2)Cl)C3CCCCC3.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
