SPR741 acetate

• CAT Number: I046027
• Molecular Formula: C46H77N13O15
• Molecular Weight: 1052.18
• Purity: ≥95%
• Synonyms: (2S,3R)-2-acetamido-3-hydroxy-N-[(2R)-3-hydroxy-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]propan-2-yl]butanamide;acetic acid
• InChI: InChI=1S/C44H73N13O13.C2H4O2/c1-22(2)19-31-40(66)52-27(11-15-45)36(62)51-29(13-17-47)39(65)57-34(23(3)59)43(69)48-18-14-30(53-42(68)33(21-58)56-44(70)35(24(4)60)49-25(5)61)38(64)50-28(12-16-46)37(63)55-32(41(67)54-31)20-26-9-7-6-8-10-26;1-2(3)4/h6-10,22-24,27-35,58-60H,11-21,45-47H2,1-5H3,(H,48,69)(H,49,61)(H,50,64)(H,51,62)(H,52,66)(H,53,68)(H,54,67)(H,55,63)(H,56,70)(H,57,65);1H3,(H,3,4)/t23-,24-,27+,28+,29+,30+,31+,32-,33-,34+,35+;/m1./s1
• InChIKey: MTXUNMBWXNZRFJ-CWNAQSEYSA-N
• SMILES: CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCCC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)CCN)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C)C(C)O)CCN)CCN.CC(=O)O

SPR741 acetate (CAT: I046027) is a cationic peptide derivative of polymyxin B developed as a potentiator molecule to enhance the efficacy of antibiotics against multidrug-resistant Gram-negative bacteria. Unlike polymyxin B, SPR741 exhibits minimal intrinsic antibacterial activity but increases outer membrane permeability, facilitating antibiotic entry into bacterial cells. It effectively potentiates drugs that are substrates of the AcrAB-TolC efflux pump, overcoming intrinsic resistance mechanisms in E. coli and other Gram-negative pathogens. SPR741 widens the antibacterial spectrum of co-administered antibiotics while offering a significantly improved safety profile compared to polymyxin B, with reduced nephrotoxicity in preclinical studies.