InChI | InChI=1S/C28H43NO8/c1-17(9-12-24-26(32)28(16-34-28)15-27(6,33-7)37-24)8-11-23-18(2)14-22(20(4)36-23)29-25(31)13-10-19(3)35-21(5)30/h8-10,12-13,18-20,22-24,26,32H,11,14-16H2,1-7H3,(H,29,31)/b12-9+,13-10-,17-8+/t18-,19-,20+,22+,23-,24+,26+,27-,28+/m0/s1 |
Reference | 1: Yoshimoto R, Kaida D, Furuno M, Burroughs AM, Noma S, Suzuki H, Kawamura Y,
Hayashizaki Y, Mayeda A, Yoshida M. Global analysis of pre-mRNA subcellular
localization following splicing inhibition by spliceostatin A. RNA. 2017
Jan;23(1):47-57. Epub 2016 Oct 17. PubMed PMID: 27754875; PubMed Central PMCID:
PMC5159648.
<br>
2: Larrayoz M, Blakemore SJ, Dobson RC, Blunt MD, Rose-Zerilli MJ, Walewska R,
Duncombe A, Oscier D, Koide K, Forconi F, Packham G, Yoshida M, Cragg MS,
Strefford JC, Steele AJ. The SF3B1 inhibitor spliceostatin A (SSA) elicits
apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1.
Leukemia. 2016 Feb;30(2):351-60. doi: 10.1038/leu.2015.286. Epub 2015 Oct 21.
PubMed PMID: 26488112.
<br>
3: Ghosh AK, Chen ZH, Effenberger KA, Jurica MS. Enantioselective total syntheses
of FR901464 and spliceostatin A and evaluation of splicing activity of key
derivatives. J Org Chem. 2014 Jun 20;79(12):5697-709. doi: 10.1021/jo500800k.
Epub 2014 May 30. PubMed PMID: 24873648; PubMed Central PMCID: PMC4066912.
<br>
4: Ghosh AK, Chen ZH. Enantioselective syntheses of FR901464 and spliceostatin A:
potent inhibitors of spliceosome. Org Lett. 2013 Oct 4;15(19):5088-91. doi:
10.1021/ol4024634. Epub 2013 Sep 19. PubMed PMID: 24050251; PubMed Central PMCID:
PMC3827971.
<br>
5: Corrionero A, Miñana B, Valcárcel J. Reduced fidelity of branch point
recognition and alternative splicing induced by the anti-tumor drug spliceostatin
A. Genes Dev. 2011 Mar 1;25(5):445-59. doi: 10.1101/gad.2014311. PubMed PMID:
21363963; PubMed Central PMCID: PMC3049286.
<br>
6: Furumai R, Uchida K, Komi Y, Yoneyama M, Ishigami K, Watanabe H, Kojima S,
Yoshida M. Spliceostatin A blocks angiogenesis by inhibiting global gene
expression including VEGF. Cancer Sci. 2010 Nov;101(11):2483-9. doi:
10.1111/j.1349-7006.2010.01686.x. PubMed PMID: 20726856.
<br>
7: Roybal GA, Jurica MS. Spliceostatin A inhibits spliceosome assembly subsequent
to prespliceosome formation. Nucleic Acids Res. 2010 Oct;38(19):6664-72. doi:
10.1093/nar/gkq494. Epub 2010 Jun 6. PubMed PMID: 20529876; PubMed Central PMCID:
PMC2965229.
<br>
8: Lo CW, Kaida D, Nishimura S, Matsuyama A, Yashiroda Y, Taoka H, Ishigami K,
Watanabe H, Nakajima H, Tani T, Horinouchi S, Yoshida M. Inhibition of splicing
and nuclear retention of pre-mRNA by spliceostatin A in fission yeast. Biochem
Biophys Res Commun. 2007 Dec 21;364(3):573-7. Epub 2007 Oct 15. PubMed PMID:
17961508.
<br>
9: Kaida D, Motoyoshi H, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H,
Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S, Yoshida M. Spliceostatin
A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nat
Chem Biol. 2007 Sep;3(9):576-83. Epub 2007 Jul 22. PubMed PMID: 17643111.
|