Spironolactone-d3

• CAT Number: I045023
• Molecular Formula: C24H29D3O4S
• Molecular Weight: 419.59
• Purity: ≥95%
• Synonyms: S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5′-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2′-oxolane]-7-yl] 2,2,2-trideuterioethanethioate
• IUPAC Name: S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] 2,2,2-trideuterioethanethioate
• InChI: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1/i1D3
• InChIKey: LXMSZDCAJNLERA-OFUZVNSWSA-N
• SMILES: [2H]C([2H])([2H])C(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]3[C@@H]1[C@@H]4CC[C@]5([C@]4(CC3)C)CCC(=O)O5)C

Spironolactone-d3（Cat No.:I045023）is a deuterium-labeled form of spironolactone, a synthetic steroid and aldosterone antagonist used primarily in hypertension, heart failure, and hormonal disorders. The incorporation of three deuterium atoms allows for precise quantification and differentiation in mass spectrometry and pharmacokinetic studies. It retains the biological activity of the parent compound, blocking mineralocorticoid receptors to promote sodium excretion and potassium retention. Spironolactone-d3 is valuable in metabolic stability testing, drug-drug interaction assessment, and bioanalytical research, offering enhanced analytical clarity without altering the pharmacological properties of the original molecule.