Spermine(N3BBB)

• CAT Number: I042598
• CAS Number: 1190203-80-5
• Molecular Formula: C25H48N6O6
• Molecular Weight: 528.69
• Purity: ≥95%
• Synonyms: tert-butyl N-(3-azidopropyl)-N-[4-[(2-methylpropan-2-yl)oxycarbonyl-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]amino]butyl]carbamate
• InChI: InChI=1S/C25H48N6O6/c1-23(2,3)35-20(32)27-14-12-18-30(21(33)36-24(4,5)6)16-10-11-17-31(19-13-15-28-29-26)22(34)37-25(7,8)9/h10-19H2,1-9H3,(H,27,32)
• InChIKey: OROLSMZGMDZZBU-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCCN(CCCCN(CCCN=[N+]=[N-])C(=O)OC(C)(C)C)C(=O)OC(C)(C)C

Spermine(N3BBB) (Cat No.: I042598) is a chemically modified derivative of spermine, a naturally occurring polyamine involved in cellular growth and DNA stabilization. This analog features an azide-functionalized benzyl group (N3BBB), enabling bioorthogonal conjugation through click chemistry. It retains the polycationic character of native spermine, facilitating interactions with nucleic acids, while the azide tag allows for selective labeling, tracking, or conjugation in biochemical assays. Spermine(N3BBB) is a useful tool in chemical biology for studying polyamine transport, nucleic acid interactions, and targeted delivery applications.

Reference

[1]. Roeland Vanhoutte, et al. Clickable Polyamine Derivatives as Chemical Probes for the Polyamine Transport System. Chembiochem. 2018 May 4;19(9):907-911.
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