SpdSyn binder-1

• CAT Number: I042474
• CAS Number: 251106-30-6
• Molecular Formula: C21H22N4O
• Molecular Weight: 346.43
• Purity: ≥95%
• Synonyms: 3H-benzimidazol-5-yl-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]methanone
• InChI: InChI=1S/C21H22N4O/c26-21(18-8-9-19-20(15-18)23-16-22-19)25-13-11-24(12-14-25)10-4-7-17-5-2-1-3-6-17/h1-9,15-16H,10-14H2,(H,22,23)/b7-4+
• InChIKey: OHZGXXXQMBAXGH-QPJJXVBHSA-N
• SMILES: C1CN(CCN1CC=CC2=CC=CC=C2)C(=O)C3=CC4=C(C=C3)N=CN4

SpdSyn binder-1 (Cat No.: I042474) is a small-molecule ligand that selectively binds to spermidine synthase (SpdSyn), an essential enzyme in the polyamine biosynthesis pathway responsible for converting putrescine to spermidine. By interacting with SpdSyn, this compound can modulate polyamine levels, which are critical for cell growth, proliferation, and differentiation. SpdSyn binder-1 serves as a valuable research tool for studying the regulation of polyamine metabolism, cancer cell proliferation, and potential antimicrobial strategies by targeting biosynthetic enzymes crucial for microbial and tumor cell viability.

Reference

[1]. Micael Jacobsson, et al. Identification of Plasmodium falciparum spermidine synthase active site binders through structure-based virtual screening. J Med Chem. 2008 May 8;51(9):2777-86.
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