For research use only. Not for therapeutic Use.
SPDMV(CAT: I017590) is a glutathione-cleavable linker designed for use in antibody–drug conjugates (ADCs). Incorporating a disulfide bond, SPDMV is engineered to remain stable in circulation while undergoing selective cleavage in the reductive intracellular environment, triggered by elevated glutathione levels in tumor cells. This mechanism ensures efficient intracellular drug release, enhancing the therapeutic index of ADCs. SPDMV provides flexibility for conjugation with a wide range of cytotoxic payloads, supporting the development of next-generation targeted therapies. Its stability, cleavability, and compatibility make it a valuable tool in ADC research for optimizing drug delivery and cancer treatment strategies.
| CAS Number | 890409-85-5 |
| Synonyms | (2,5-dioxopyrrolidin-1-yl) 4-methyl-4-(pyridin-2-yldisulfanyl)pentanoate |
| Molecular Formula | C15H18N2O4S2 |
| Purity | ≥95% |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 4-methyl-4-(pyridin-2-yldisulfanyl)pentanoate |
| InChI | InChI=1S/C15H18N2O4S2/c1-15(2,23-22-11-5-3-4-10-16-11)9-8-14(20)21-17-12(18)6-7-13(17)19/h3-5,10H,6-9H2,1-2H3 |
| InChIKey | GOJXFKVHNIGABU-UHFFFAOYSA-N |
| SMILES | CC(C)(CCC(=O)ON1C(=O)CCC1=O)SSC2=CC=CC=N2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
