For research use only. Not for therapeutic Use.
SPD304 dihydrochloride(CAT: I017246) is a selective TNF-α inhibitor that promotes dissociation of TNF trimers, thereby blocking TNF-α interaction with its receptor. It exhibits an IC₅₀ of 22 μM for inhibiting TNFR1 binding to TNF-α in vitro. SPD304 (2 μM) enhances survivability of activated hepatic stellate cells (aHSCs), decreases lipid hydroxide production, and increases intracellular GSH levels. In combination with GA, SPD304 downregulates TRADD and p-RIP3 expression while promoting caspase-8 activation, highlighting its role in apoptosis regulation. Due to high systemic toxicity, SPD304 is unsuitable for in vivo use, but remains a valuable tool in TNF-α signaling research.
| CAS Number | 1049741-03-8 |
| Synonyms | 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride |
| Molecular Formula | C32H34Cl2F3N3O2 |
| Purity | ≥95% |
| IUPAC Name | 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride |
| InChI | InChI=1S/C32H32F3N3O2.2ClH/c1-21-14-28-30(15-22(21)2)40-20-24(31(28)39)18-37(4)13-12-36(3)17-23-19-38(29-11-6-5-10-27(23)29)26-9-7-8-25(16-26)32(33,34)35;;/h5-11,14-16,19-20H,12-13,17-18H2,1-4H3;2*1H |
| InChIKey | GOZMBJCYMQQACI-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(C=C1C)OC=C(C2=O)CN(C)CCN(C)CC3=CN(C4=CC=CC=C43)C5=CC=CC(=C5)C(F)(F)F.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
