SPD-304 - CAS 869998-49-2

SPD-304 (CAT: I009569) is an inhibitor of tumor necrosis factor α (TNFα), specifically targeting its binding to the TNF receptor 1 (TNFR1). With an IC50 of 22 µM, SPD-304 effectively blocks the interaction between TNFα and TNFR1. TNFα is a cytokine involved in inflammatory processes and immune responses. The inhibition of TNFα signaling by SPD-304 may have implications in the treatment of conditions characterized by excessive TNFα activity, such as inflammatory disorders. Additionally, both TNFα and the angiotensin II/angiotensin II receptor type 1 (AT1) axis have been implicated in neuropathic pain and nociception, suggesting a potential role for SPD-304 in modulating these processes.

Catalog Number: I009569

CAS Number: 869998-49-2

PubChem Substance ID:355426585

Molecular Formula: C32H32F3N3O2

Molecular Weight:547.622

Purity: ≥95%

* For research use only. Not for human or veterinary use.


SynonymsSPD-304, SPD 304, SPD304.;6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-4H-1-benzopyran-4-one


Molecular Formula: C32H32F3N3O2
Molecular Weight547.622
Target:TNFα inhibitor
SolubilitySoluble in DMSO

Computed Descriptor

IUPAC Name6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one