For research use only. Not for therapeutic Use.
SPA70（Cat No.:I044358）is a selective antagonist of the human pregnane X receptor (PXR), a nuclear receptor involved in the regulation of genes linked to drug metabolism and transport, including cytochrome P450 enzymes like CYP3A4. Unlike many PXR modulators, SPA70 functions as an antagonist without exhibiting partial agonist activity, making it a valuable tool for dissecting PXR-mediated transcriptional regulation. By blocking PXR activation, SPA70 can reduce drug-drug interactions and influence chemoresistance mechanisms in cancer therapy. Its specificity and lack of agonist effects make it promising for pharmacological and toxicological research.
| CAS Number | 931314-31-7 |
| Synonyms | 4-(4-tert-butylphenyl)sulfonyl-1-(2,5-dimethoxyphenyl)-5-methyltriazole |
| Molecular Formula | C21H25N3O4S |
| Purity | ≥95% |
| IUPAC Name | 4-(4-tert-butylphenyl)sulfonyl-1-(2,5-dimethoxyphenyl)-5-methyltriazole |
| InChI | InChI=1S/C21H25N3O4S/c1-14-20(29(25,26)17-10-7-15(8-11-17)21(2,3)4)22-23-24(14)18-13-16(27-5)9-12-19(18)28-6/h7-13H,1-6H3 |
| InChIKey | OIOPHIFJQXHPAF-UHFFFAOYSA-N |
| SMILES | CC1=C(N=NN1C2=C(C=CC(=C2)OC)OC)S(=O)(=O)C3=CC=C(C=C3)C(C)(C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
