For research use only. Not for therapeutic Use.
SP4206(CAT: I017182) is a potent small-molecule inhibitor of the IL-2/IL-2Rα interaction, designed to disrupt cytokine–receptor signaling. It binds with high affinity to IL-2 (Kd = 70 nM) and effectively blocks its interaction with the natural receptor IL-2Rα (Kd = 10 nM). SP4206 demonstrates activity across multiple IL-2 variants, with EC₅₀ values of 68.8 nM (WT IL-2), 80.1 nM (K35L/M39V), 117.0 nM (P65A), and 10.4 nM (V69A). By selectively modulating IL-2 signaling, SP4206 is a valuable chemical probe for immunology, cancer immunotherapy, and cytokine biology research, supporting studies on T cell regulation and immune checkpoint pathways.
| CAS Number | 515846-21-6 |
| Synonyms | 5-[[2,3-dichloro-4-[5-[1-[2-[[(2R)-2-(diaminomethylideneamino)-4-methylpentanoyl]amino]acetyl]piperidin-4-yl]-1-methylpyrazol-3-yl]phenoxy]methyl]furan-2-carboxylic acid |
| Molecular Formula | C30H37Cl2N7O6 |
| Purity | ≥95% |
| IUPAC Name | 5-[[2,3-dichloro-4-[5-[1-[2-[[(2R)-2-(diaminomethylideneamino)-4-methylpentanoyl]amino]acetyl]piperidin-4-yl]-1-methylpyrazol-3-yl]phenoxy]methyl]furan-2-carboxylic acid |
| InChI | InChI=1S/C30H37Cl2N7O6/c1-16(2)12-21(36-30(33)34)28(41)35-14-25(40)39-10-8-17(9-11-39)22-13-20(37-38(22)3)19-5-7-23(27(32)26(19)31)44-15-18-4-6-24(45-18)29(42)43/h4-7,13,16-17,21H,8-12,14-15H2,1-3H3,(H,35,41)(H,42,43)(H4,33,34,36)/t21-/m1/s1 |
| InChIKey | VNZHOIDQBPFEJU-OAQYLSRUSA-N |
| SMILES | CC(C)CC(C(=O)NCC(=O)N1CCC(CC1)C2=CC(=NN2C)C3=C(C(=C(C=C3)OCC4=CC=C(O4)C(=O)O)Cl)Cl)N=C(N)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
