SP 600125, negative control

• CAT Number: R065996
• CAS Number: 54642-23-8
• Molecular Formula: C15H10N2O
• Molecular Weight: 234.258
• Purity: ≥95%
• Storage: -20°C
• InChI: InChI=1S/C15H10N2O/c1-17-12-8-4-7-11-13(12)14(16-17)9-5-2-3-6-10(9)15(11)18/h2-8H,1H3
• InChIKey: ODZGYELAMAOARP-UHFFFAOYSA-N
• SMILES: CN1C2=CC=CC3=C2C(=N1)C4=CC=CC=C4C3=O

SP 600125 (Item No. 10010466) is a selective, cell-permeable, reversible inhibitor of JNK isoforms 1-3 with Ki values of 0.19 μM. SP 600125, negative control is a methylated analog of SP 600125 that has much lower affinity for JNK isoforms (IC50s = 18 and 24 µM for JNK2 and JNK3, respectively).

Reference

1.Bennett, B.L.,Sasaki, D.T.,Murray, B.W., et al. SP600125, an anthrapyrazolone inhibitor of jun N-terminal kinase. Proceedings of the National Academy of Sciences of the United States of America 98(24), 13681-13686 (2001).