SP-100030

• CAT Number: I011161
• CAS Number: 154563-54-9
• Molecular Formula: C14H5ClF9N3O
• Molecular Weight: 437.65
• Purity: ≥95%
• Synonyms: N-[3,5-bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide
• InChI: InChI=1S/C14H5ClF9N3O/c15-11-25-4-8(9(27-11)14(22,23)24)10(28)26-7-2-5(12(16,17)18)1-6(3-7)13(19,20)21/h1-4H,(H,26,28)
• InChIKey: GHMKQBWHPQMXSH-UHFFFAOYSA-N
• SMILES: C1=C(C=C(C=C1C(F)(F)F)NC(=O)C2=CN=C(N=C2C(F)(F)F)Cl)C(F)(F)F

SP-100030 (Cat No.: I011161) is a small-molecule research compound investigated for its role as an inhibitor of nuclear factor kappa B (NF-κB) signaling, a pathway central to inflammation, immune regulation, and cancer progression. By blocking NF-κB activation, SP-100030 reduces transcription of pro-inflammatory cytokines and survival-related genes. Researchers use it to study immune responses, inflammatory diseases, and tumor biology. While not developed for therapeutic application, SP-100030 serves as a valuable pharmacological probe in understanding NF-κB–mediated processes and exploring drug discovery strategies targeting inflammatory pathways.

Reference

[1]. Sullivan RW, et al. 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3′,5′- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-kappa B- and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry. J Med Chem. 1998;4
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[2]. Gerlag DM, et al. The effect of a T cell-specific NF-kappa B inhibitor on in vitro cytokine production and collagen-induced arthritis. J Immunol. 2000;165(3):1652-1658.
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