For research use only. Not for therapeutic Use.
Sovilnesib (Cat No.: I036521) is a selective kinesin spindle protein (KSP, also called Eg5) inhibitor developed for the treatment of cancer. By targeting KSP, a motor protein essential for mitotic spindle formation, sovilnesib disrupts proper chromosome segregation during mitosis, leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells. It is particularly effective in hematologic malignancies and solid tumors with high mitotic activity. Sovilnesib has shown promising antitumor activity in clinical trials, with a favorable safety profile.
| CAS Number | 2410796-79-9 |
| Synonyms | 2-(6-azaspiro[2.5]octan-6-yl)-N-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-(2-hydroxyethylsulfonylamino)benzamide |
| Molecular Formula | C26H34F2N6O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C26H34F2N6O4S/c1-18-16-22(31-24(29-18)34-12-8-26(27,28)9-13-34)30-23(36)20-3-2-19(32-39(37,38)15-14-35)17-21(20)33-10-6-25(4-5-25)7-11-33/h2-3,16-17,32,35H,4-15H2,1H3,(H,29,30,31,36) |
| InChIKey | KBDGEJDIHZDPHN-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NC(=N1)N2CCC(CC2)(F)F)NC(=O)C3=C(C=C(C=C3)NS(=O)(=O)CCO)N4CCC5(CC5)CC4 |
| Reference | [1]. Payton MN, et, al. Kif18a inhibitors for treatment of neoplastic diseases. WO2021211549 [2]. Tamayo NA, et, al. Kif18a inhibitors. WO2020132648. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
