Sodium bis(trimethylsilyl)amide

• CAT Number: M069198
• CAS Number: 1070-89-9
• Molecular Formula: C6H18NNaSi2
• Molecular Weight: 183.38
• Purity: ≥95%
• Storage: Room temperature
• IUPAC Name: sodium;bis(trimethylsilyl)azanide
• InChI: InChI=1S/C6H18NSi2.Na/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1
• InChIKey: WRIKHQLVHPKCJU-UHFFFAOYSA-N
• SMILES: C[Si](C)(C)[N-][Si](C)(C)C.[Na+]

Sodium bis(trimethylsilyl)amide (Cat No.:M069198) is a strong, non-nucleophilic base commonly used in organic synthesis. It consists of a sodium cation and a bulky bis(trimethylsilyl)amide anion, which provides excellent steric hindrance and minimal nucleophilicity. NaHMDS is highly effective for generating enolates, deprotonating weakly acidic protons, and facilitating elimination or condensation reactions under mild conditions. It is typically supplied as a solution in tetrahydrofuran (THF) or hexane for ease of handling. Its stability, solubility, and selectivity make it essential in organometallic chemistry, peptide coupling, and the synthesis of sensitive or complex molecules.