For research use only. Not for therapeutic Use.
SNX7886(CAT: I040561) is a potent PROTAC (proteolysis-targeting chimera) degrader specifically designed to target cyclin-dependent kinases CDK8 and CDK19. By harnessing the cell’s ubiquitin-proteasome system, SNX7886 induces selective degradation of CDK8 (90%) and CDK19 (80%) in 293 cells. This targeted degradation disrupts transcriptional regulation and mediator complex activity, offering a precise approach to modulate oncogenic signaling pathways. SNX7886 is an advanced chemical biology tool for studying transcriptional control, epigenetic regulation, and CDK-driven tumorigenesis. It holds potential in the development of novel anticancer strategies where CDK8/19 activity contributes to disease progression. Suitable for in vitro and mechanistic studies.
| CAS Number | 2924557-42-4 |
| Synonyms | 4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]-N-[11-[4-[2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]acetyl]piperazin-1-yl]-11-oxoundecyl]butanamide |
| Molecular Formula | C52H59N9O7 |
| Purity | ≥95% |
| IUPAC Name | 4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]-N-[11-[4-[2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]acetyl]piperazin-1-yl]-11-oxoundecyl]butanamide |
| InChI | InChI=1S/C52H59N9O7/c62-45(17-12-26-54-43-16-11-15-41-49(43)52(68)61(51(41)67)44-23-24-46(63)57-50(44)66)55-25-10-6-4-2-1-3-5-7-18-47(64)58-27-29-59(30-28-58)48(65)35-60-34-39(32-56-60)36-19-21-37(22-20-36)42-33-53-31-38-13-8-9-14-40(38)42/h8-9,11,13-16,19-22,31-34,44,54H,1-7,10,12,17-18,23-30,35H2,(H,55,62)(H,57,63,66) |
| InChIKey | BGFPHKGFAIAVCS-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCC(=O)NCCCCCCCCCCC(=O)N4CCN(CC4)C(=O)CN5C=C(C=N5)C6=CC=C(C=C6)C7=CN=CC8=CC=CC=C87 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
