SN-008

• CAT Number: I045192
• CAS Number: 2249106-01-0
• Molecular Formula: C25H19FN2O3S
• Molecular Weight: 446.49
• Purity: ≥95%
• Synonyms: N-[3-[(4-fluorophenyl)sulfonylamino]phenyl]-4-phenylbenzamide
• InChI: InChI=1S/C25H19FN2O3S/c26-21-13-15-24(16-14-21)32(30,31)28-23-8-4-7-22(17-23)27-25(29)20-11-9-19(10-12-20)18-5-2-1-3-6-18/h1-17,28H,(H,27,29)
• InChIKey: GFQARWFKDMDSAS-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)NC3=CC(=CC=C3)NS(=O)(=O)C4=CC=C(C=C4)F

SN-008（Cat No.:I045192）is a potent, selective inhibitor of the NLRP3 inflammasome, a key regulator of innate immunity that controls activation of caspase-1 and maturation of IL-1β and IL-18. By blocking NLRP3 activation, SN-008 suppresses excessive inflammation and pyroptosis, offering therapeutic potential for autoimmune, metabolic, and neurodegenerative diseases. It has shown strong activity in preclinical models of gout, type 2 diabetes, atherosclerosis, and Alzheimer’s disease. SN-008 is a valuable research tool for elucidating inflammasome signaling and developing targeted anti-inflammatory strategies aimed at NLRP3-driven pathological conditions while maintaining normal immune defense.