SMD-3040 intermediate-2

• CAT Number: I040505
• CAS Number: 2632308-00-8
• Molecular Formula: C21H28ClN3O2
• Molecular Weight: 389.92
• Purity: ≥95%
• Synonyms: tert-butyl 2-(3-chloro-4-cyanophenyl)-3-methyl-2,8-diazaspiro[4.5]decane-8-carboxylate
• IUPAC Name: Tert-butyl 2-(3-chloro-4-cyanophenyl)-3-methyl-2,8-diazaspiro[4.5]decane-8-carboxylate
• InChI: InChI=1S/C21H28ClN3O2/c1-15-12-21(7-9-24(10-8-21)19(26)27-20(2,3)4)14-25(15)17-6-5-16(13-23)18(22)11-17/h5-6,11,15H,7-10,12,14H2,1-4H3
• InChIKey: WXLUHNJCOLNWIB-UHFFFAOYSA-N
• SMILES: CC1CC2(CCN(CC2)C(=O)OC(C)(C)C)CN1C3=CC(=C(C=C3)C#N)Cl

SMD-3040 Intermediate-2(CAT: I040505) is a key synthetic intermediate in the preparation of SMD-3040 (HY-156568), a selective SMARCA2 degrader designed for targeted protein degradation strategies. SMD-3040 integrates SMARCA2/4-binding ligands, a linker, and VHL ligands to recruit the E3 ubiquitin ligase complex, enabling selective degradation of SMARCA2 while sparing SMARCA4. Intermediate-2 serves as a critical building block in assembling this bifunctional molecule and is useful for developing PROTACs and ADC-based therapeutics. SMD-3040 has demonstrated potent antitumor activity in xenograft models. This intermediate is ideal for researchers working on targeted degradation platforms and next-generation cancer therapeutics. Supplied in high purity for synthesis applications.