For research use only. Not for therapeutic Use.
SM-433（Cat No.:I044649）is a potent Smac-mimetic small molecule that functions as an antagonist of inhibitor of apoptosis proteins (IAPs), particularly XIAP. By mimicking the activity of endogenous Smac/DIABLO, it disrupts IAP–caspase interactions, thereby promoting caspase activation and inducing apoptosis in cancer cells. SM-433 exhibits strong cytotoxicity in tumor cell lines such as MDA-MB-231 and SK-OV-3, with submicromolar IC₅₀ values. It is supplied as a highly pure solid and is soluble in DMSO and water. SM-433 is widely used in cancer research to explore apoptotic pathways and develop targeted therapies.
| CAS Number | 1071992-81-8 |
| Synonyms | (5S,8S,10aR)-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-N-[(2-phenylphenyl)methyl]-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide |
| Molecular Formula | C32H43N5O4 |
| Purity | ≥95% |
| IUPAC Name | (5S,8S,10aR)-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-N-[(2-phenylphenyl)methyl]-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide |
| InChI | InChI=1S/C32H43N5O4/c1-21(2)18-29(38)36-17-16-25-14-15-28(37(25)32(41)27(20-36)35-30(39)22(3)33-4)31(40)34-19-24-12-8-9-13-26(24)23-10-6-5-7-11-23/h5-13,21-22,25,27-28,33H,14-20H2,1-4H3,(H,34,40)(H,35,39)/t22-,25+,27-,28-/m0/s1 |
| InChIKey | SZVCBOBNBHXZKC-MZRLSVQCSA-N |
| SMILES | C[C@@H](C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NCC3=CC=CC=C3C4=CC=CC=C4)C(=O)CC(C)C)NC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
