For research use only. Not for therapeutic Use.
SM-360320（Cat No.:I009525）is a small-molecule compound recognized for its potent inhibition of human DNA polymerase β, an enzyme critical for base excision repair in DNA damage response pathways. By targeting polymerase β, SM-360320 interferes with DNA repair, enhancing the cytotoxicity of DNA-damaging agents and making it a promising adjuvant in cancer therapy. It is commonly used in preclinical research to study DNA repair mechanisms, genomic stability, and drug sensitivity in tumor cells. Its selective inhibition profile supports its role in understanding polymerase β-associated resistance in chemotherapeutic treatment strategies.
| CAS Number | 226907-52-4 |
| Synonyms | 6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8-one |
| Molecular Formula | C15H17N5O3 |
| Purity | ≥95% |
| IUPAC Name | 6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8-one |
| InChI | InChI=1S/C15H17N5O3/c1-22-7-8-23-14-18-12(16)11-13(19-14)20(15(21)17-11)9-10-5-3-2-4-6-10/h2-6H,7-9H2,1H3,(H,17,21)(H2,16,18,19) |
| InChIKey | YYCDGEZXHXHLGW-UHFFFAOYSA-N |
| SMILES | COCCOC1=NC(=C2C(=N1)N(C(=O)N2)CC3=CC=CC=C3)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
