For research use only. Not for therapeutic Use.
SM-1295（Cat No.:I044371）is a selective small molecule inhibitor of SUMO-specific protease 1 (SENP1), an enzyme involved in deSUMOylation, a key post-translational modification regulating protein stability, localization, and activity. By inhibiting SENP1, SM-1295 disrupts SUMOylation homeostasis, affecting processes such as cell cycle progression, apoptosis, and transcriptional regulation. It has shown potential in cancer research, where SENP1 is often overexpressed and contributes to tumor development and progression. SM-1295 is a valuable chemical probe for exploring SUMOylation pathways and their roles in cancer and other cellular processes.
| CAS Number | 1562375-46-5 |
| Synonyms | (5S,8S,10aR)-N-[(4-bromophenyl)methyl]-5-[[(2S)-2-(methylamino)propanoyl]amino]-6-oxo-3-(2-phenylacetyl)-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide |
| Molecular Formula | C29H36BrN5O4 |
| Purity | ≥95% |
| IUPAC Name | (5S,8S,10aR)-N-[(4-bromophenyl)methyl]-5-[[(2S)-2-(methylamino)propanoyl]amino]-6-oxo-3-(2-phenylacetyl)-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide |
| InChI | InChI=1S/C29H36BrN5O4/c1-19(31-2)27(37)33-24-18-34(26(36)16-20-6-4-3-5-7-20)15-14-23-12-13-25(35(23)29(24)39)28(38)32-17-21-8-10-22(30)11-9-21/h3-11,19,23-25,31H,12-18H2,1-2H3,(H,32,38)(H,33,37)/t19-,23+,24-,25-/m0/s1 |
| InChIKey | SOTHWYAWZKSXSA-CTZQYXLCSA-N |
| SMILES | C[C@@H](C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NCC3=CC=C(C=C3)Br)C(=O)CC4=CC=CC=C4)NC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
