SLMP53-1

• CAT Number: I043475
• CAS Number: 1643469-17-3
• Molecular Formula: C20H18N2O2
• Molecular Weight: 318.37
• Purity: ≥95%
• Synonyms: (3S,9bR)-3-(1H-indol-3-ylmethyl)-9b-methyl-2,3-dihydro-[1,3]oxazolo[2,3-a]isoindol-5-one
• InChI: InChI=1S/C20H18N2O2/c1-20-17-8-4-2-7-16(17)19(23)22(20)14(12-24-20)10-13-11-21-18-9-5-3-6-15(13)18/h2-9,11,14,21H,10,12H2,1H3/t14-,20+/m0/s1
• InChIKey: RSAFMLBHKXOCJG-VBKZILBWSA-N
• SMILES: C[C@@]12C3=CC=CC=C3C(=O)N1[C@H](CO2)CC4=CNC5=CC=CC=C54

SLMP53-1（Cat No.:I043475）is a small molecule inhibitor that targets the MDM2-p53 interaction, aiming to restore the tumor-suppressive activity of p53, a critical protein involved in cell cycle regulation and apoptosis. In many cancers, MDM2 overexpression leads to the degradation of p53, allowing tumor cells to evade cell death. By inhibiting the MDM2-p53 interaction, SLMP53-1 stabilizes p53 and promotes its tumor-suppressive effects, potentially leading to cancer cell death. This compound is being studied for its therapeutic potential in treating cancers with disrupted p53 signaling, offering a targeted approach to tumor suppression.