SLK/STK10-IN-1

• CAT Number: I045343
• CAS Number: 264210-49-3
• Molecular Formula: C17H13ClN2O3
• Molecular Weight: 328.75
• Purity: ≥95%
• Synonyms: 3-(3-chloroanilino)-4-(2-methoxyphenyl)pyrrole-2,5-dione
• InChI: InChI=1S/C17H13ClN2O3/c1-23-13-8-3-2-7-12(13)14-15(17(22)20-16(14)21)19-11-6-4-5-10(18)9-11/h2-9H,1H3,(H2,19,20,21,22)
• InChIKey: DQYDZCRLDYVZKY-UHFFFAOYSA-N
• SMILES: COC1=CC=CC=C1C2=C(C(=O)NC2=O)NC3=CC(=CC=C3)Cl

SLK/STK10‑IN‑1 (Cat No.: I045343) is a potent dual inhibitor targeting STE20-like kinase SLK and serine/threonine kinase STK10, with nanomolar-range biochemical potency and high kinome-wide selectivity. In cellular assays, SLK/STK10‑IN‑1 inhibits ERM protein activation, alters cell morphology, and blocks lymphocyte migration and cell-cycle progression, showing potential antitumor activity in preclinical studies. It is used as a biochemical tool to investigate cytoskeletal regulation, immune cell signaling, and SLK/STK10-driven oncogenic pathways.

Reference

[1]. Serafim RAM, et al. Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold. J Med Chem. 2021 Sep 23;64(18):13259-13278.
[Content Brief]