For research use only. Not for therapeutic Use.
SKLB-197（Cat No.:I045195）is a potent, orally bioavailable multitargeted tyrosine kinase inhibitor with strong activity against vascular endothelial growth factor receptors (VEGFRs), fibroblast growth factor receptors (FGFRs), and platelet-derived growth factor receptors (PDGFRs). By blocking these angiogenic and proliferative signaling pathways, SKLB-197 suppresses tumor growth, metastasis, and neovascularization. It has demonstrated significant antitumor efficacy in preclinical cancer models, particularly those dependent on aberrant angiogenesis. SKLB-197 is a valuable research tool for studying tumor angiogenesis and kinase signaling, with therapeutic potential for treating a broad spectrum of solid tumors and angiogenesis-related disorders.
| CAS Number | 2713577-16-1 |
| Synonyms | (3R)-4-[2-(1H-indol-4-yl)-6-(2-methylpyrazol-3-yl)quinazolin-4-yl]-3-methylmorpholine |
| Molecular Formula | C25H24N6O |
| Purity | ≥95% |
| IUPAC Name | (3R)-4-[2-(1H-indol-4-yl)-6-(2-methylpyrazol-3-yl)quinazolin-4-yl]-3-methylmorpholine |
| InChI | InChI=1S/C25H24N6O/c1-16-15-32-13-12-31(16)25-20-14-17(23-9-11-27-30(23)2)6-7-22(20)28-24(29-25)19-4-3-5-21-18(19)8-10-26-21/h3-11,14,16,26H,12-13,15H2,1-2H3/t16-/m1/s1 |
| InChIKey | FCNFJRRMUAOHKI-MRXNPFEDSA-N |
| SMILES | C[C@@H]1COCCN1C2=NC(=NC3=C2C=C(C=C3)C4=CC=NN4C)C5=C6C=CNC6=CC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
