SKF 83959

• CAT Number: I036356
• CAS Number: 80751-85-5
• Molecular Formula: C18H20ClNO2
• Molecular Weight: 317.81
• Purity: ≥95%
• Synonyms: 9-chloro-3-methyl-5-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
• InChI: InChI=1S/C18H20ClNO2/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3
• InChIKey: JXMYTVOBSFOHAF-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC=C1)C2CN(CCC3=C(C(=C(C=C23)O)O)Cl)C

SKF 8395 (Cat No.: I036356) is a dopaminergic agonist that selectively stimulates dopamine receptors, particularly within the central nervous system, influencing motor control, reward pathways, and neuroendocrine regulation. It has been used in neuroscience research to study dopaminergic signaling, Parkinson’s disease models, and the role of dopamine in behavior and mood regulation. By mimicking dopamine activity, SKF 8395 can modulate neurotransmission and neuroplasticity. This compound serves as a valuable pharmacological tool for probing dopamine receptor function and exploring therapeutic approaches for dopamine-related neurological disorders.

Reference

[1]. Sheng G, et al. SKF83959 Has Protective Effects in the Scopolamine Model of Dementia. Biol Pharm Bull. 2018;41(3):427-434.
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[2]. Jin LQ, et al. SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain. J Neurochem. 2003;85(2):378-386.
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[3]. Neumeyer JL, et al. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur J Pharmacol. 2003;474(2-3):137-140.
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[4]. Guo L, et al. SKF83959 is a potent allosteric modulator of sigma-1 receptor. Mol Pharmacol. 2013;83(3):577-586.
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