For research use only. Not for therapeutic Use.
SK33(CAT: I016844) is a trifluoromethylated enobosarm analog that acts as a potent, tissue-selective anti-androgen by reducing androgen receptor (AR) transcriptional activity. In prostate cancer models, SK33 demonstrates strong inhibitory effects with an IC₅₀ of 0.2 μM in LNCaP-AR⁺ cells, where it significantly reduces S-phase entry. In LNCaP/BicR cells, SK33 suppresses cell growth in a dose-dependent manner with an IC₅₀ of ~5 μM after 96 hours. In vivo, SK33 (50 mg/kg; s.c.; 24 h) effectively inhibits AR-driven transcription. With its potency and tissue selectivity, SK33 represents a promising probe for AR-targeted cancer research and therapeutic exploration.
| CAS Number | 1928724-23-5 |
| Synonyms | 3-[3,5-bis(trifluoromethyl)phenoxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide |
| Molecular Formula | C20H13F9N2O3 |
| Purity | ≥95% |
| IUPAC Name | 3-[3,5-bis(trifluoromethyl)phenoxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide |
| InChI | InChI=1S/C20H13F9N2O3/c1-17(33,16(32)31-13-3-2-10(8-30)15(7-13)20(27,28)29)9-34-14-5-11(18(21,22)23)4-12(6-14)19(24,25)26/h2-7,33H,9H2,1H3,(H,31,32) |
| InChIKey | VJIVKRQGSGBLFP-UHFFFAOYSA-N |
| SMILES | CC(COC1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
