For research use only. Not for therapeutic Use.
SK-3-91（Cat No.:I044103）is a potent small-molecule STAT3 inhibitor that disrupts Signal Transducer and Activator of Transcription 3 (STAT3) signaling, a pathway frequently hyperactivated in cancer and inflammatory diseases. It inhibits STAT3 by blocking phosphorylation, dimerization, and DNA binding, thereby suppressing transcription of genes involved in cell survival, proliferation, and immune evasion. SK-3-91 is particularly useful in targeting STAT3-dependent tumors, such as multiple myeloma, breast cancer, and pancreatic cancer. It is widely used in oncology and immunology research to investigate transcriptional regulation, drug resistance, and to develop targeted therapeutic strategies.
| CAS Number | 2769753-23-1 |
| Synonyms | N-[2-[2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]ethoxy]ethyl]-2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetamide |
| Molecular Formula | C42H47ClN10O8S |
| Purity | ≥95% |
| IUPAC Name | N-[2-[2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]ethoxy]ethyl]-2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetamide |
| InChI | InChI=1S/C42H47ClN10O8S/c1-26(2)62(59,60)34-9-4-3-7-31(34)48-38-30(43)24-46-42(50-38)47-27-10-12-28(13-11-27)52-19-17-51(18-20-52)21-23-61-22-16-44-36(55)25-45-32-8-5-6-29-37(32)41(58)53(40(29)57)33-14-15-35(54)49-39(33)56/h3-13,24,26,33,45H,14-23,25H2,1-2H3,(H,44,55)(H,49,54,56)(H2,46,47,48,50) |
| InChIKey | NFXUYJNRWVKYFF-UHFFFAOYSA-N |
| SMILES | CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=CC=C(C=C3)N4CCN(CC4)CCOCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
