SJM-3

• CAT Number: I045436
• CAS Number: 1234977-97-9
• Molecular Formula: C18H15FN4OS
• Molecular Weight: 354.40
• Purity: ≥95%
• Synonyms: (6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-yl)-(2-pyrazin-2-yl-1,3-thiazol-4-yl)methanone
• InChI: InChI=1S/C18H15FN4OS/c1-11-2-3-12-8-13(19)4-5-16(12)23(11)18(24)15-10-25-17(22-15)14-9-20-6-7-21-14/h4-11H,2-3H2,1H3
• InChIKey: MCMRMBOJJFVNHG-UHFFFAOYSA-N
• SMILES: CC1CCC2=C(N1C(=O)C3=CSC(=N3)C4=NC=CN=C4)C=CC(=C2)F

SJM-3 (Cat No.: I045436) is a small-molecule inhibitor targeting indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme that catalyzes the first step in tryptophan catabolism along the kynurenine pathway. By blocking IDO1 activity, SJM-3 reduces immunosuppressive kynurenine production, thereby enhancing T-cell proliferation and restoring anti-tumor immune responses. It is used in cancer immunology research to explore strategies for overcoming tumor-induced immune evasion and can be combined with checkpoint inhibitors. SJM-3 also serves as a tool for studying tryptophan metabolism in inflammation and immune regulation.

Reference

[1]. Simon J Middendorp, et al. Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site. Neuropharmacology. 2015 Aug;95:459-67.
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