For research use only. Not for therapeutic Use.
SJ6986 (Cat No.: I045398) is a small-molecule compound identified as a selective inhibitor of EED, a core component of the Polycomb Repressive Complex 2 (PRC2). By disrupting PRC2 activity, SJ6986 modulates epigenetic silencing of target genes, influencing cell differentiation and proliferation. It has been studied in preclinical models for its role in epigenetic regulation, particularly in glioblastoma and other cancers. SJ6986 is a valuable research tool for investigating chromatin dynamics and potential therapeutic strategies involving epigenetic reprogramming.
| CAS Number | 2765625-93-0 |
| Synonyms | N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-(trifluoromethoxy)benzenesulfonamide |
| Molecular Formula | C20H14F3N3O7S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H14F3N3O7S/c21-20(22,23)33-14-3-1-2-4-15(14)34(31,32)25-10-5-6-11-12(9-10)19(30)26(18(11)29)13-7-8-16(27)24-17(13)28/h1-6,9,13,25H,7-8H2,(H,24,27,28) |
| InChIKey | RKAFYSIKAVFVPS-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NS(=O)(=O)C4=CC=CC=C4OC(F)(F)F |
| Reference | [1]. Gisele Nishiguchi, et al. Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators. J Med Chem. 2021 May 27. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
