For research use only. Not for therapeutic Use.
SIS3 free base（Cat No.:I046090）is a potent and selective inhibitor of SMAD3, a key intracellular mediator of transforming growth factor-β (TGF-β) signaling. By blocking SMAD3 phosphorylation and transcriptional activity, SIS3 suppresses TGF-β–driven processes such as fibrosis, epithelial-to-mesenchymal transition (EMT), and immune regulation. The free base form provides flexibility for experimental applications in cell-based and biochemical studies. Widely used in preclinical research, SIS3 free base enables exploration of pathological mechanisms in fibrosis, cancer, and inflammatory diseases, supporting the development of therapeutic strategies targeting TGF-β/SMAD3 signaling pathways.
| CAS Number | 521985-36-4 |
| Synonyms | (E)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one |
| Molecular Formula | C28H27N3O3 |
| Purity | ≥95% |
| IUPAC Name | (E)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one |
| InChI | InChI=1S/C28H27N3O3/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31/h4-12,14,16-17H,13,15,18H2,1-3H3/b12-11+ |
| InChIKey | IJYPHMXWKKKHGT-VAWYXSNFSA-N |
| SMILES | CN1C(=C(C2=C1N=CC=C2)/C=C/C(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
