SIRT5 inhibitor 3

• CAT Number: I043682
• CAS Number: 2128651-12-5
• Molecular Formula: C22H12FN3O4
• Molecular Weight: 401.35
• Purity: ≥95%
• Synonyms: 4-[5-[(E)-2-cyano-3-(4-cyano-3-fluoroanilino)-3-oxoprop-1-enyl]furan-2-yl]benzoic acid
• InChI: InChI=1S/C22H12FN3O4/c23-19-10-17(6-5-15(19)11-24)26-21(27)16(12-25)9-18-7-8-20(30-18)13-1-3-14(4-2-13)22(28)29/h1-10H,(H,26,27)(H,28,29)/b16-9+
• InChIKey: ZXUUSUJEPKBBBB-CXUHLZMHSA-N
• SMILES: C1=CC(=CC=C1C2=CC=C(O2)/C=C(\C#N)/C(=O)NC3=CC(=C(C=C3)C#N)F)C(=O)O

SIRT5 inhibitor 3（Cat No.:I043682）is a selective small molecule designed to target and inhibit SIRT5 (Sirtuin 5), an NAD+-dependent deacylase involved in regulating cellular metabolism and mitochondrial function. SIRT5 plays a role in modulating protein desuccinylation and demalonylation, which affects various metabolic pathways, including those in cancer, neurodegenerative diseases, and metabolic disorders. By inhibiting SIRT5, SIRT5 inhibitor 3 can alter metabolic processes and influence cellular stress responses, offering potential therapeutic benefits in diseases associated with dysregulated metabolism, aging, and mitochondrial dysfunction. It holds promise for targeting metabolic disorders and age-related diseases.