Sincalide ammonium

• CAT Number: I046034
• CAS Number: 70706-98-8
• Molecular Formula: C49H65N11O16S3
• Molecular Weight: 1160.30
• Purity: ≥95%
• Synonyms: (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxo-3-(4-sulfooxyphenyl)propan-2-yl]amino]-4-oxobutanoic acid;azane
• InChI: InChI=1S/C49H62N10O16S3.H3N/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27;/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74);1H3/t32-,34-,35-,36-,37-,38-,39-;/m0./s1
• InChIKey: SKHSHPLUIPFDPM-ITZXPNBCSA-N
• SMILES: CSCCC(C(=O)NCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)OS(=O)(=O)O)NC(=O)C(CC(=O)O)N.N

Sincalide ammonium (CAT: I046034) is an octapeptide analogue of cholecystokinin (CCK) that retains the major bioactive functions of the natural hormone. Clinically, it is used for intravenous administration in postevacuation cholecystography to promote gallbladder contraction, bile secretion, and sphincter of Oddi relaxation, aiding in the diagnosis of gallbladder and pancreatic disorders. Beyond gastrointestinal effects, CCK-8 has emerged as a cardiovascular hormone, showing inhibitory activity against myocardial fibrosis, apoptosis, and collagen deposition. In experimental models, Sincalide ammonium protects cardiomyoblasts from Ang II–induced apoptosis via CCK1 receptor and PI3K/Akt signaling, alleviates fibrosis, and delays left ventricular remodeling in heart failure.