For research use only. Not for therapeutic Use.
Silvestrol aglycone (enantiomer)（Cat No.:I017940）is a flavagline derivative structurally related to silvestrol, originally isolated from Aglaia species. It is a potent modulator of protein translation, acting through selective inhibition of the eukaryotic initiation factor eIF4A. By blocking cap-dependent mRNA translation, it suppresses the expression of oncogenic and survival-related proteins, leading to antiproliferative and pro-apoptotic effects. Silvestrol aglycone (enantiomer) demonstrates strong anticancer activity in preclinical studies, particularly against hematologic malignancies and solid tumors. Its unique mechanism makes it a valuable tool for cancer research and therapeutic development.
| CAS Number | 1112993-18-6 |
| Synonyms | methyl (1S,2S,3R,3aS,8bR)-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate |
| Molecular Formula | C27H26O8 |
| Purity | ≥95% |
| IUPAC Name | methyl (1S,2S,3R,3aS,8bR)-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate |
| InChI | InChI=1S/C27H26O8/c1-32-18-11-9-16(10-12-18)27-22(15-7-5-4-6-8-15)21(25(30)34-3)24(29)26(27,31)23-19(33-2)13-17(28)14-20(23)35-27/h4-14,21-22,24,28-29,31H,1-3H3/t21-,22-,24-,26+,27+/m0/s1 |
| InChIKey | HYLOONIBWUNKDH-DSVANHEQSA-N |
| SMILES | COC1=CC=C(C=C1)[C@@]23[C@H]([C@@H]([C@@H]([C@@]2(C4=C(O3)C=C(C=C4OC)O)O)O)C(=O)OC)C5=CC=CC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
