For research use only. Not for therapeutic Use.
SI-109（Cat No.:I017777）is a potent and selective inhibitor of the transcription factor STAT3, a key regulator of cell proliferation, survival, and immune evasion. By disrupting STAT3 activation and downstream gene transcription, SI-109 suppresses oncogenic signaling pathways implicated in tumor growth and resistance. This compound is a valuable tool for exploring STAT3-driven mechanisms in cancer biology, immunology, and inflammation. Its targeted inhibition supports research into therapeutic strategies aimed at overcoming drug resistance and modulating immune responses, making SI-109 an important candidate for translational and preclinical studies.
| CAS Number | 2429877-30-3 |
| Synonyms | [[2-[[(5S,8S,10aR)-3-acetyl-8-[[(2S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl]carbamoyl]-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl]-1H-indol-5-yl]-difluoromethyl]phosphonic acid |
| Molecular Formula | C40H44F2N7O9P |
| Purity | ≥95% |
| IUPAC Name | [[2-[[(5S,8S,10aR)-3-acetyl-8-[[(2S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl]carbamoyl]-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl]-1H-indol-5-yl]-difluoromethyl]phosphonic acid |
| InChI | InChI=1S/C40H44F2N7O9P/c1-23(50)48-19-18-28-13-16-33(38(54)45-30(15-17-34(43)51)36(52)47-35(24-8-4-2-5-9-24)25-10-6-3-7-11-25)49(28)39(55)32(22-48)46-37(53)31-21-26-20-27(12-14-29(26)44-31)40(41,42)59(56,57)58/h2-12,14,20-21,28,30,32-33,35,44H,13,15-19,22H2,1H3,(H2,43,51)(H,45,54)(H,46,53)(H,47,52)(H2,56,57,58)/t28-,30+,32+,33+/m1/s1 |
| InChIKey | HBICZHLVBCLHSV-VUCLUUCHSA-N |
| SMILES | CC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)C3=CC4=C(N3)C=CC(=C4)C(F)(F)P(=O)(O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)NC(C5=CC=CC=C5)C6=CC=CC=C6 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
