SHP2 protein degrader-2

• CAT Number: I043702
• CAS Number: 2740582-16-3
• Molecular Formula: C56H79ClN12O6S2
• Molecular Weight: 1115.89
• Purity: ≥95%
• Synonyms: (2R,4S)-1-[(2R)-2-[9-[4-[4-[3-[3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl]sulfanyl-2-chloroanilino]-4-oxobutanoyl]piperazin-1-yl]nonanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C56H79ClN12O6S2/c1-36(38-17-19-39(20-18-38)49-37(2)61-35-76-49)62-52(74)42-32-40(70)34-69(42)54(75)50(55(3,4)5)65-45(71)16-11-9-7-8-10-12-25-66-28-30-68(31-29-66)47(73)22-21-46(72)63-41-14-13-15-43(48(41)57)77-53-51(58)64-44(33-60-53)67-26-23-56(6,59)24-27-67/h13-15,17-20,33,35-36,40,42,50,70H,7-12,16,21-32,34,59H2,1-6H3,(H2,58,64)(H,62,74)(H,63,72)(H,65,71)/t36-,40+,42-,50+/m1/s1
• InChIKey: XJSPAQRZSJUBLB-ISSNAGQGSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](C)NC(=O)[C@H]3C[C@@H](CN3C(=O)[C@@H](C(C)(C)C)NC(=O)CCCCCCCCN4CCN(CC4)C(=O)CCC(=O)NC5=C(C(=CC=C5)SC6=NC=C(N=C6N)N7CCC(CC7)(C)N)Cl)O

SHP2 protein degrader-2（Cat No.:I043702）is a small molecule designed to selectively degrade SHP2 (Src homology region 2 domain-containing phosphatase-2), a protein tyrosine phosphatase involved in key signaling pathways that regulate cell growth, differentiation, and survival. SHP2 plays a critical role in various cancers, particularly in resistance to targeted therapies. By recruiting the cellular machinery responsible for protein degradation, SHP2 protein degrader-2 selectively reduces SHP2 levels, potentially halting tumor progression and overcoming drug resistance. This approach offers a novel strategy for targeting SHP2-driven malignancies and improving cancer therapy outcomes.