SHP2-D26

• CAT Number: I045168
• CAS Number: 2458219-65-1
• Molecular Formula: C56H79ClN12O6S2
• Molecular Weight: 1115.89
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[(2S)-2-[9-[4-[4-[3-[3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl]sulfanyl-2-chloroanilino]-4-oxobutanoyl]piperazin-1-yl]nonanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C56H79ClN12O6S2/c1-36(38-17-19-39(20-18-38)49-37(2)61-35-76-49)62-52(74)42-32-40(70)34-69(42)54(75)50(55(3,4)5)65-45(71)16-11-9-7-8-10-12-25-66-28-30-68(31-29-66)47(73)22-21-46(72)63-41-14-13-15-43(48(41)57)77-53-51(58)64-44(33-60-53)67-26-23-56(6,59)24-27-67/h13-15,17-20,33,35-36,40,42,50,70H,7-12,16,21-32,34,59H2,1-6H3,(H2,58,64)(H,62,74)(H,63,72)(H,65,71)/t36-,40+,42-,50+/m0/s1
• InChIKey: XJSPAQRZSJUBLB-WQFCSRJTSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCN4CCN(CC4)C(=O)CCC(=O)NC5=C(C(=CC=C5)SC6=NC=C(N=C6N)N7CCC(CC7)(C)N)Cl)O

SHP2-D26（Cat No.:I045168）is a potent, selective allosteric inhibitor of SHP2 (Src homology region 2-containing protein tyrosine phosphatase-2), a key signaling protein involved in RAS/MAPK pathway regulation. By stabilizing SHP2 in its inactive conformation, SHP2-D26 blocks downstream oncogenic signaling, reducing cell proliferation and survival. It shows promise in targeting cancers driven by aberrant SHP2 activity, including RAS-mutant and receptor tyrosine kinase–driven tumors. SHP2-D26 is also a valuable research tool for studying SHP2-mediated pathways in oncology and developmental biology, aiding drug discovery focused on precision cancer therapeutics and signal transduction modulation.