Shikonin

• CAT Number: I003868
• CAS Number: 517-89-5
• Molecular Formula: C₁₆H₁₆O₅
• Molecular Weight: 288.3
• Purity: ≥95%
• Target: target: TMEM16A chloride channel [1]
• Solubility: DMSO ≥ 31 mg/mL
• Storage: -20°C
• InChI: InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3
• InChIKey: NEZONWMXZKDMKF-UHFFFAOYSA-N
• SMILES: CC(=CCC(C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C

Shikonin (CAT: I003868) is a naturally occurring naphthoquinone compound derived from the roots of the plant Lithospermum erythrorhizon. It possesses various pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer properties. Shikonin has been traditionally used in traditional Chinese medicine for its wound healing and anti-inflammatory effects. It has shown promising potential as an anticancer agent, exhibiting inhibitory effects on various cancer cell lines and tumor growth. Shikonin’s mechanism of action involves the modulation of multiple signaling pathways, including apoptosis, cell cycle regulation, and inflammation. Furthermore, it has been investigated for its potential therapeutic applications in dermatological disorders and microbial infections.

Reference

[1]. Jiang Y et al. Shikonin Inhibits Intestinal Calcium-Activated Chloride Channels and Prevents Rotaviral Diarrhea. Front Pharmacol. 2016 Aug 23;7:270.

[2]. Fu D et al. Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis. Exp Ther Med. 2016 Oct;12(4):2735-2740.

[3]. Zorman J et al. Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1. PLoS One. 2016 Jul 28