For research use only. Not for therapeutic Use.
SHA 68(CAT: I010971) is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC₅₀ values of 22.0 nM (NPSR Asn107) and 23.8 nM (NPSR Ile107). It demonstrates limited blood-brain barrier penetration and has been evaluated for neuralgia-related activity. In vivo, SHA 68 (i.p.; 5–50 mg/kg) reduces NPS-induced locomotor activity, including horizontal movement, rearing, and climbing. Pharmacokinetic studies show rapid clearance and short half-life: SHA 68 (i.v.; 1 mg/kg) exhibits T₁/₂ of 0.74 h, CL of 4.29 mL/min/kg, and Vss of 2.53 L/kg, while (i.p.; 2.5 mg/kg) yields T₁/₂ of 0.43 h and CL of 4.56 mL/min/kg.
CAS Number | 847553-89-3 |
Molecular Formula | C26H24FN3O3 |
Purity | ≥95% |
IUPAC Name | N-[(4-fluorophenyl)methyl]-3-oxo-1,1-diphenyl-5,6,8,8a-tetrahydro-[1,3]oxazolo[3,4-a]pyrazine-7-carboxamide |
InChI | InChI=1S/C26H24FN3O3/c27-22-13-11-19(12-14-22)17-28-24(31)29-15-16-30-23(18-29)26(33-25(30)32,20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23H,15-18H2,(H,28,31) |
InChIKey | SFRQIPRTNYHJHP-UHFFFAOYSA-N |
SMILES | C1CN2C(CN1C(=O)NCC3=CC=C(C=C3)F)C(OC2=O)(C4=CC=CC=C4)C5=CC=CC=C5 |
Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |