For research use only. Not for therapeutic Use.
SGK1-IN-4（Cat No.:I044164）is a selective small-molecule inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1), a serine/threonine kinase involved in regulating ion transport, cell survival, and stress responses. SGK1 is implicated in various pathological conditions, including hypertension, cancer, fibrosis, and metabolic disorders. By inhibiting SGK1 activity, SGK1-IN-4 modulates downstream signaling pathways such as PI3K/AKT and mTOR, affecting cellular proliferation, apoptosis, and sodium reabsorption. SGK1-IN-4 is widely used in preclinical research to investigate SGK1’s role in disease progression and evaluate its potential as a therapeutic target in oncology, nephrology, and endocrine disorders.
| CAS Number | 1628048-93-0 |
| Synonyms | 5-chloro-2-fluoro-N-[4-[4-(4-hydroxycyclohexyl)oxy-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]benzenesulfonamide |
| Molecular Formula | C23H21ClFN5O4S |
| Purity | ≥95% |
| IUPAC Name | 5-chloro-2-fluoro-N-[4-[4-(4-hydroxycyclohexyl)oxy-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]benzenesulfonamide |
| InChI | InChI=1S/C23H21ClFN5O4S/c24-14-3-10-19(25)20(11-14)35(32,33)30-15-4-1-13(2-5-15)21-27-22-18(12-26-29-22)23(28-21)34-17-8-6-16(31)7-9-17/h1-5,10-12,16-17,30-31H,6-9H2,(H,26,27,28,29) |
| InChIKey | IKBMUGXVSJZWGW-UHFFFAOYSA-N |
| SMILES | C1CC(CCC1O)OC2=NC(=NC3=C2C=NN3)C4=CC=C(C=C4)NS(=O)(=O)C5=C(C=CC(=C5)Cl)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
