For research use only. Not for therapeutic Use.
SGK1-IN-2（Cat No.:I016200）is a potent and selective inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1), a serine/threonine kinase involved in ion transport, cell survival, and stress response pathways. By blocking SGK1 activity, SGK1-IN-2 is used to study mechanisms underlying cancer progression, metabolic syndrome, hypertension, and inflammatory disorders. This compound enables researchers to probe SGK1’s role in signaling networks related to PI3K/AKT and mTOR pathways. Its specificity makes it a valuable pharmacological tool in chemical biology, drug discovery, and therapeutic exploration targeting kinase-regulated cellular processes.
| CAS Number | 1426214-64-3 |
| Synonyms | N-[4-(3-amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,5-dichlorobenzenesulfonamide |
| Molecular Formula | C17H12Cl2N6O2S |
| Purity | ≥95% |
| IUPAC Name | N-[4-(3-amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,5-dichlorobenzenesulfonamide |
| InChI | InChI=1S/C17H12Cl2N6O2S/c18-10-3-6-12(19)14(7-10)28(26,27)25-11-4-1-9(2-5-11)13-8-21-15-16(20)23-24-17(15)22-13/h1-8,25H,(H3,20,22,23,24) |
| InChIKey | RTERCHJCWXQPSS-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C2=NC3=NNC(=C3N=C2)N)NS(=O)(=O)C4=C(C=CC(=C4)Cl)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
