• CAT Number: I000143
  • CAS Number: 1020149-73-8
  • Molecular Formula: C₂₇H₂₃N₇O
  • Molecular Weight: 461.52
  • Purity: ≥95%
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SGI-1027 (Cat No.:I000143) is a DNMT inhibitor for DNMT1, DNMT3A and DNMT3B with IC50 of 6, 8 and 7.5 μM in cell-free assays, respectively. SGI‑1027 induces apoptosis. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Catalog Number I000143
CAS Number 1020149-73-8
Molecular Formula


Purity 95%
Target Histone Methyltransferase
Solubility DMSO: ≤ 27 mg/mL
Storage 2-8°C
IC50 6/8/7.5 uM (DNMT1/3A/3B)
IUPAC Name N-[4-[(2-amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide
InChI InChI=1S/C27H23N7O/c1-17-16-25(34-27(28)30-17)32-20-10-12-21(13-11-20)33-26(35)18-6-8-19(9-7-18)31-24-14-15-29-23-5-3-2-4-22(23)24/h2-16H,1H3,(H,29,31)(H,33,35)(H3,28,30,32,34)

</br>1:Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation. Rilova E, Erdmann A, Gros C, Masson V, Aussagues Y, Poughon-Cassabois V, Rajavelu A, Jeltsch A, Menon Y, Novosad N, Gregoire JM, Vispé S, Schambel P, Ausseil F, Sautel F, Arimondo PB, Cantagrel F.ChemMedChem. 2014 Mar;9(3):590-601. doi: 10.1002/cmdc.201300420. PMID: 24678024 Free PMC Article</br>2:Molecular modeling studies of the novel inhibitors of DNA methyltransferases SGI-1027 and CBC12: implications for the mechanism of inhibition of DNMTs. Yoo J, Choi S, Medina-Franco JL.PLoS One. 2013 Apr 25;8(4):e62152. doi: 10.1371/journal.pone.0062152. Print 2013. PMID: 23637988 Free PMC Article</br>3:Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line. García-Domínguez P, Dell/’aversana C, Alvarez R, Altucci L, de Lera AR.Bioorg Med Chem Lett. 2013 Mar 15;23(6):1631-5. doi: 10.1016/j.bmcl.2013.01.085. Epub 2013 Jan 30. PMID: 23402879

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