For research use only. Not for therapeutic Use.
SGC-SMARCA-BRDVIII（Cat No.:I036279）is a selective chemical probe designed to inhibit the bromodomain of SMARCA2 and SMARCA4, key components of the SWI/SNF chromatin remodeling complex. These ATP-dependent chromatin remodelers regulate gene expression by altering nucleosome positioning. By targeting their bromodomains, SGC-SMARCA-BRDVIII disrupts protein–protein interactions involved in transcriptional regulation without affecting ATPase activity. It is used to explore the non-catalytic roles of SMARCA proteins in cancer and epigenetics. Supplied by the Structural Genomics Consortium, this probe supports research into chromatin remodeling, transcriptional control, and epigenetic therapeutic development.
| CAS Number | 1997319-84-2 |
| Synonyms | tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate |
| Molecular Formula | C19H25N5O3 |
| Purity | ≥95% |
| IUPAC Name | tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate |
| InChI | InChI=1S/C19H25N5O3/c1-19(2,3)27-18(26)24-10-8-23(9-11-24)15-12-14(21-22-17(15)20)13-6-4-5-7-16(13)25/h4-7,12,25H,8-11H2,1-3H3,(H2,20,22) |
| InChIKey | AQTNUGRRZDRZIA-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)N1CCN(CC1)C2=CC(=NN=C2N)C3=CC=CC=C3O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
