For research use only. Not for therapeutic Use.
SGC-AAK1-1(Cat No.:I017874)is a selective, cell-permeable small-molecule inhibitor of AP2-associated protein kinase 1 (AAK1), a serine/threonine kinase involved in clathrin-mediated endocytosis and receptor trafficking. By blocking AAK1 activity, SGC-AAK1-1 modulates cellular uptake pathways and neurotransmitter receptor regulation. It is a valuable chemical probe for studying endocytosis, synaptic function, and signaling networks influenced by AAK1. This compound also provides insights into potential therapeutic strategies for neurological disorders, pain, and viral entry processes. Its potency and selectivity make it a trusted tool for mechanistic biology research.
CAS Number | 2247894-32-0 |
Synonyms | N-[6-[3-(diethylsulfamoylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide |
Molecular Formula | C21H25N5O3S |
Purity | ≥95% |
IUPAC Name | N-[6-[3-(diethylsulfamoylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide |
InChI | InChI=1S/C21H25N5O3S/c1-3-26(4-2)30(28,29)25-17-7-5-6-15(12-17)16-10-11-18-19(13-16)23-24-20(18)22-21(27)14-8-9-14/h5-7,10-14,25H,3-4,8-9H2,1-2H3,(H2,22,23,24,27) |
InChIKey | UCBIQZUJJSVQHL-UHFFFAOYSA-N |
SMILES | CCN(CC)S(=O)(=O)NC1=CC=CC(=C1)C2=CC3=C(C=C2)C(=NN3)NC(=O)C4CC4 |
Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |