SGC-AAK1-1

• CAT Number: I017874
• CAS Number: 2247894-32-0
• Molecular Formula: C21H25N5O3S
• Molecular Weight: 427.52
• Purity: ≥95%
• Synonyms: N-[6-[3-(diethylsulfamoylamino)phenyl]-1H-indazol-3-yl]cyclopropanecarboxamide
• InChI: InChI=1S/C21H25N5O3S/c1-3-26(4-2)30(28,29)25-17-7-5-6-15(12-17)16-10-11-18-19(13-16)23-24-20(18)22-21(27)14-8-9-14/h5-7,10-14,25H,3-4,8-9H2,1-2H3,(H2,22,23,24,27)
• InChIKey: UCBIQZUJJSVQHL-UHFFFAOYSA-N
• SMILES: CCN(CC)S(=O)(=O)NC1=CC=CC(=C1)C2=CC3=C(C=C2)C(=NN3)NC(=O)C4CC4

SGC-AAK1-1（Cat No.:I017874）is a selective, cell-permeable small-molecule inhibitor of AP2-associated protein kinase 1 (AAK1), a serine/threonine kinase involved in clathrin-mediated endocytosis and receptor trafficking. By blocking AAK1 activity, SGC-AAK1-1 modulates cellular uptake pathways and neurotransmitter receptor regulation. It is a valuable chemical probe for studying endocytosis, synaptic function, and signaling networks influenced by AAK1. This compound also provides insights into potential therapeutic strategies for neurological disorders, pain, and viral entry processes. Its potency and selectivity make it a trusted tool for mechanistic biology research.