SETDB1-TTD-IN-1

• CAT Number: I045266
• CAS Number: 2755823-12-0
• Molecular Formula: C28H31N5O2
• Molecular Weight: 469.58
• Purity: ≥95%
• Synonyms: 2-[[(3R,5R)-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-3-prop-2-enyl-5H-pyrrolo[3,2-d]pyrimidin-4-one
• InChI: InChI=1S/C28H31N5O2/c1-3-15-33-27(34)26-25(13-14-29-26)31-28(33)30-23-16-22(17-32(2)18-23)21-9-11-24(12-10-21)35-19-20-7-5-4-6-8-20/h3-14,22-23,29H,1,15-19H2,2H3,(H,30,31)/t22-,23+/m0/s1
• InChIKey: NBDJDKAXIGWAIM-XZOQPEGZSA-N
• SMILES: CN1C[C@H](C[C@H](C1)NC2=NC3=C(C(=O)N2CC=C)NC=C3)C4=CC=C(C=C4)OCC5=CC=CC=C5

SETDB1-TTD-IN-1（Cat No.:I045266）is a selective inhibitor targeting the Tudor tandem domain (TTD) of SETDB1, a histone methyltransferase responsible for trimethylating histone H3 lysine 9 (H3K9me3), a key epigenetic mark associated with transcriptional repression and heterochromatin formation. By disrupting TTD-mediated recognition of methylated histones, SETDB1-TTD-IN-1 interferes with SETDB1’s chromatin recruitment and gene-silencing functions. This compound is valuable for studying SETDB1’s role in epigenetic regulation, cancer progression, and neurological disorders. Its potency and specificity make it a powerful research tool for probing chromatin biology and developing SETDB1-targeted therapeutic strategies in oncology and beyond.