Sertraline hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: A000649
  • CAS Number: 79559-97-0
  • Molecular Formula: C17H18Cl3N
  • Molecular Weight: 342.69
  • Purity: ≥95%
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Sertraline hydrochloride(Cat No.:A000649)is a selective serotonin reuptake inhibitor (SSRI) with the molecular formula C17H17Cl2N·HCl, commonly prescribed to treat depression, anxiety disorders, panic disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). It works by inhibiting the reuptake of serotonin in the brain, enhancing mood and emotional stability. Administered orally, sertraline is well-tolerated and typically taken once daily. Common side effects include nausea, insomnia, dizziness, and sexual dysfunction. It offers a favorable safety profile and is widely used in both adult and pediatric psychiatric care.


CAS Number 79559-97-0
Synonyms

(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride

Molecular Formula C17H18Cl3N
Purity ≥95%
IUPAC Name (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride
InChI InChI=1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChIKey BLFQGGGGFNSJKA-XHXSRVRCSA-N
SMILES CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl
Reference

[1]. Murdoch D, et al. Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder. Drugs. 1992 Oct;44(4):604-24.
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[2]. Koe BK. Preclinical pharmacology of sertraline: a potent and specific inhibitor of serotonin reuptake. J Clin Psychiatry. 1990 Dec;51 Suppl B:13-7.
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[3]. Xiang X, et, al. Anti-depressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- And TNF-α/TNFR1-mediated NF-κB Activation. ACS Chem Neurosci. 2020 Jul 1.
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[4]. Lei M, et, al. Sex Differences in Antidepressant Effect of Sertraline in Transgenic Mouse Models. Front Cell Neurosci. 2019 Feb 1; 13:24.
[Content Brief]

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