For research use only. Not for therapeutic Use.
Senaparib (Cat No.:I036215) is a potent, orally bioavailable PARP1/2 inhibitor designed to exploit synthetic lethality in tumors with homologous recombination repair (HRR) deficiencies, such as BRCA1/2 mutations. By inhibiting PARP-mediated DNA repair, senaparib induces accumulation of DNA damage, leading to cancer cell death. It has demonstrated strong antitumor activity in preclinical models and early clinical trials, particularly in ovarian and breast cancers. Senaparib shows improved selectivity and tolerability compared to earlier PARP inhibitors, making it a promising candidate for targeted cancer therapy in HR-deficient malignancies.
| CAS Number | 1401682-78-7 |
| Synonyms | 5-fluoro-1-[[4-fluoro-3-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]quinazoline-2,4-dione |
| Molecular Formula | C24H20F2N6O3 |
| Purity | ≥95% |
| IUPAC Name | 5-fluoro-1-[[4-fluoro-3-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]quinazoline-2,4-dione |
| InChI | InChI=1S/C24H20F2N6O3/c25-17-6-5-15(14-32-19-4-1-3-18(26)20(19)21(33)29-24(32)35)13-16(17)22(34)30-9-11-31(12-10-30)23-27-7-2-8-28-23/h1-8,13H,9-12,14H2,(H,29,33,35) |
| InChIKey | VBTUJTGLLREMNW-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1C2=NC=CC=N2)C(=O)C3=C(C=CC(=C3)CN4C5=C(C(=CC=C5)F)C(=O)NC4=O)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
