SEL24-B489 HCl - CAS 1616359-00-2

SEL24-B489 HCl(Cat No.:I036190) is a novel, orally available, dual PIM/FLT3 kinase inhibitor. It inhibits FLT3 wild-type and FLT3-ITD mutant kinase activities in nanomolar concentrations, leading to reduced proliferation and induction of apoptosis in acute myeloid leukemia (AML) cell lines and primary patient samples. In addition, SEL24-B489 HCl targets the PIM kinase family, which is involved in cell survival, proliferation, and drug resistance. This dual inhibition of FLT3 and PIM kinases makes SEL24-B489 HCl a promising candidate for the treatment of FLT3-mutant AML.

Catalog Number: I036190

CAS Number: 1616359-00-2

Molecular Formula: C15H19Br2ClN4O2

Molecular Weight:482.60

Purity: 98.0%

Appearance:Solid powder

* For research use only. Not for human or veterinary use.


SynonymsSEL24 Hydrochloride; SEL-24 Hydrochloride; SEL 24 Hydrochloride; SEL24 HCl; SEL 24 HCl; SEL-24 HCl; SEL24B489 HCl; SEL24 B489 HCl; SEL24-B489 HCl


Molecular Formula: C15H19Br2ClN4O2
Molecular Weight482.60
SolubilitySoluble in DMSO
StorageStore at -20°C

Computed Descriptor

IUPAC Name5,6-Dibromo-4-nitro-2-(piperidin-4-yl)-1-(propan-2-yl)-1H-1,3-benzodiazole hydrochloride