SEC inhibitor KL-1

• CAT Number: I018143
• CAS Number: 900308-84-1
• Molecular Formula: C18H16ClNO4
• Molecular Weight: 345.78
• Purity: ≥95%
• Synonyms: (Z)-N-(5-chloro-2-methylphenyl)-4-hydroxy-4-(3-methoxyphenyl)-2-oxobut-3-enamide
• IUPAC Name: N-(5-chloro-2-methylphenyl)-4-hydroxy-4-(3-methoxyphenyl)-2-oxobut-3-enamide
• InChI: InChI=1S/C18H16ClNO4/c1-11-6-7-13(19)9-15(11)20-18(23)17(22)10-16(21)12-4-3-5-14(8-12)24-2/h3-10,21H,1-2H3,(H,20,23)
• InChIKey: ARTVILCEXNCVIN-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)Cl)NC(=O)C(=O)C=C(C2=CC(=CC=C2)OC)O

SEC inhibitor KL-1（Cat No.:I018143）is a small-molecule compound that targets the Super Elongation Complex (SEC), a critical regulator of transcriptional elongation and gene expression. By disrupting SEC function, KL-1 interferes with RNA polymerase II activity, suppressing transcription of oncogenes and other genes essential for tumor cell survival. This inhibition provides insight into transcriptional control and epigenetic regulation in cancer. Researchers employ KL-1 to study SEC-driven oncogenic programs and evaluate therapeutic approaches aimed at transcriptional vulnerabilities. KL-1 is a valuable tool for advancing oncology research.