For research use only. Not for therapeutic Use.
Sebetralstat (Cat No.: I036172) is an oral, on-demand inhibitor of plasma kallikrein, developed for the treatment of hereditary angioedema (HAE), a rare genetic disorder characterized by recurrent episodes of severe swelling. By selectively inhibiting kallikrein, sebetralstat prevents the excessive generation of bradykinin, a key mediator of vascular permeability and swelling in HAE. Designed for rapid absorption and action, sebetralstat offers a convenient alternative to injectable therapies. It is currently in clinical development and shows promise for improving quality of life for HAE patients.
| CAS Number | 1933514-13-6 |
| Synonyms | N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-[[4-[(2-oxopyridin-1-yl)methyl]phenyl]methyl]pyrazole-4-carboxamide |
| Molecular Formula | C26H26FN5O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H26FN5O4/c1-35-17-22-20(26(34)29-13-21-25(27)23(36-2)10-11-28-21)16-32(30-22)15-19-8-6-18(7-9-19)14-31-12-4-3-5-24(31)33/h3-12,16H,13-15,17H2,1-2H3,(H,29,34) |
| InChIKey | KGMPDQIYDKKXRD-UHFFFAOYSA-N |
| SMILES | COCC1=NN(C=C1C(=O)NCC2=NC=CC(=C2F)OC)CC3=CC=C(C=C3)CN4C=CC=CC4=O |
| Reference | [1]. WO2016083820 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
